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Diagnosing Miscarriage Diagnosing the Problem
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Before I begin, let me say that I know it is frustrating and
scary to face both trying again immediately or testing for causes before trying
again. Both approaches are difficult. We'd all be much happier if we could just
have had that first baby without any complication. But life has already thrown
us off course. Becoming a parent is not going to be easy for us, and we have to
face that. The information here is not really my opinion,
although I will throw a few in there. This is just the way the medical world
thinks. I wish that when we lost a baby, we could get quick and easy testing
that would tell us what went wrong, then we could do something simple that would
totally prevent it from happening again. But that is not the way it works.
Sometimes the only way to know there is a problem for sure is to lose another
baby. I hate that, and am troubled by the practice, but the medical world goes
by statistics, and here is why you may not be as aggressively tested as you
would like following your first miscarriage:
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After one miscarriage, your odds of another one are very
small. Less than 20% of women who have miscarried will have repeated losses,
so most doctors will assume that if you are healthy and had only one loss,
particularly in the first trimester, that you will never have another one.
This is pretty much true.
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There are very few treatments to help you prevent a
miscarriage. (See the section on prevention for
more.) Most testing will not uncover a reason for a loss anyway, as early
testing is just a shot in the dark. Even if testing showed a problem, there
might not be anything more you can do than to assess the amount of risk you
face for another one. The biggest bulk of miscarriages are caused by a
random genetic error, which cannot be predicted or avoided. Naturally, there
are a few treatable problems. It might pay to learn more about them in the causes
section to see if you might be a candidate.
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Testing, which often yields no answers, can be expensive,
time consuming, stressful, and make you wait longer to try again. Often by
the time you do any of the more involved testing, such as endometrial
biopsy, HSG, or laparoscopy, all of which require you to wait until a
certain time in your cycle, you could be pregnant again with a healthy baby.
After one loss, from a statistics standpoint, it makes sense just to try
again since you will almost always have a healthy baby the next time. If you
face another loss, it can make you angry that another baby had to die, and
this is perfectly understandable. But this anger and determination will get
you through the testing process and make you stronger as you face the
results.
That addresses the issue of testing after one loss. Some of you,
however, may have special circumstances: If you are over 35
and had one first trimester loss, you will be even less likely to get testing
since the odds that your loss was a chromosomal problem with your egg are very
high. There is nothing to do in this case but to keep trying for a better egg.
Some doctors, however, acknowledge that older moms might have undiagnosed health
problems, and will test for the more common thyroid or lupus causes. If
you have had two miscarriages in a row, or a loss after 14 weeks, you
will stand a better chance of getting some testing done. Those random genetic
flaws really should not strike twice in a row, and most babies with them have
already been lost before the end of the first trimester. You can usually get
some testing done with minimal fuss. After three miscarriages
in a row, you really should stop trying on your own. You clearly do have a
problem, and you need to find it and see if it can be treated. This, of course,
if only true if you have never had a healthy baby. If you have had children
between the losses, the choice to test is up to you. Your problem, if you do
have one, is obviously intermittent. The
Testing Process
A number of tests are easy to perform (blood test or vaginal
culture only.) All but a few require that you not yet be pregnant again. If you
are comfortable with your doctor and willing to fight for some testing, you can
usually ask for and get the early testing ones done even after one loss: Early
Testing
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Progesterone monitoring by blood test (prior to pregnancy to
check for luteal phase defect, and during early pregnancy to watch for
deficiencies.) |
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Mycoplasma bacteria culture from cervix |
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Antinuclear and antiphospholipid antibodies in blood |
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Lupus Anticoagulant in blood |
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Underactive or overactive thyroid by blood |
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Exposure to German Measles, toxoplasmosis, Group B
Streptococcus, or sexually transmitted diseases even if you tested negative
prior to or early in pregnancy |
More Extensive Testing
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Progesterone Endometrial Biopsy (a bit of lining is scraped
and checked) |
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Hysterosalpingogram (HSG) or "dye test" (dye is
shot into the uterus and fallopian tubes and then x-rayed to look for
malformations, fibroids, or blocked tubes) |
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Karyotyping of Baby or Pregnancy Tissue (tissue is grown in
a dish to watch for cell division, which will reveal the chromosomal make up
of the baby) |
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High Level Ultrasound of Reproductive Organs |
Most Extensive Testing (some are
limited to specialized centers and not available to regular OB/Gyns)
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Laparoscopy or Hysteroscopy (minor surgical procedures where
interior of reproduction organs are inspected with a lighted scope via a
belly button incision (lap) or up through the dilated cervix) |
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Karyotyping Parents (blood cells are cultured and grown) |
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Genetic Counseling |
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Immune Factors
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Antipaternal Leukocyte Antibodies |
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Antithyroid Antibodies |
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DQ Alpha |
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DQ Beta |
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Immunophenotype |
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Natural Killer Cell Assay |
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Tumor Nerosis Factor |
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Factor II (prothrombin) Mutation |
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Factor V Leiden Mutation |
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Methylene Tetrahydrofolate Reductase Mutation |
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Special Situation Testing
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Parvovirus, or Fifth Disease (a recently active virus can be
looked for if you work with small children, were exposed to the illness, or
had symptoms. Most adults are already immune, but this test can see if you
were not and perhaps were infected during pregnancy.) |
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Mercury blood levels (if exposure seemed high, usually
through job function) |
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